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Endocannabinoid System: A Simple Guide

by Arthur Jair
A vital receptor that plays a big role to keep human body active

The endogenous system (ECS), also known as the endocannabinoid system, is an ancient evolved system connected to the human body. It is designed to help maintain homeostasis to manage a balanced body. An endocannabinoid was discovered when exploring the effects of cannabis on the body and mind in ancient times. In the process, the researchers also discovered that the human body has cannabinoid receptors.

They are cellular proteins that respond to chemicals and are distributed throughout the body. Not only that, but they also discovered that the human body produces a class of chemicals called endocannabinoids that can interact with these cell receptors. This interaction between ECS and receptors can affect the human body and brain. To the researchers’ surprise, THC and CBD share the same compounds as ECS.

The only difference is that CBD and THC come from plants to be consumed, and ECS exists naturally and chemically in the human body. We can safely say that human beings have a system that can interact with cannabinoids. The endocannabinoid system is a broad study, and the researchers are still onto it. This article will know more about the researched studies of how exactly the endocannabinoid system works in the human body.
But, first-

How Does The Endocannabinoid System Work?

Experts do not yet have wholly proven studies to show how exactly ECS helps the human body. Most of the benefits bring visible changes to a person. But, before we go into the basics of ECS, we first need to understand how the entire system works.

To understand how the Endocannabinoid System or ECS works, we need first to know its core components. ECS consists of three core components. They are mentioned below.

Endocannabinoid Receptors

Endocannabinoids tie to the receptors present in our bodies to flag that the ECS needs to make a move. However, there are two fundamental endocannabinoid receptors. One being CB1 receptors and another CB2 receptor. CB1 receptors are generally present in the central nervous system whereas, CB2 receptors are primarily present in our peripheral nervous system. Endocannabinoids carry the power to tie to either of the receptors. Depending on which, the outcome relies upon where the receptor is present and which endocannabinoid it ties to.

In simpler terms, endocannabinoids will tie to CB1 receptors in the spinal cord to relieve the pain. On the other hand, it will also bind with CB2 receptors to treat inflammation.


Endocannabinoids are also known as Endogenous Cannabinoids. These are the molecules present in our bodies. You could say it is similar to cannabinoids. However, the only difference is that it is present in your body already. You do not need to consume CBD or THC. Endocannabinoids are naturally present in our bodies.

To date, experts could only identify two different types of Endocannabinoids present in human bodies; Anandamide (AEA) and 2-Arachidonoylglyerol (2-AG). These Endocannabinoids help the internal function to process with ease.


Once the endocannabinoids have performed their part, enzymes tend to break them down. The two responsible enzymes are fatty acid amide hydrolase and monoacylglycerol acid lipase. Fatty acid amide hydrolase breaks down AEA, while monoacylglycerol acid lipase breaks down 2-AG.

The Endocannabinoids System Structure And Function

Endocannabinoid system

The entire process of the Endocannabinoid System Structure is still unclear to the experts as they continue to study more about the molecule. However, with the help of previous studies, the experts have linked the following functions of The Endocannabinoids system structure and function:

  • Motor Control
  • Mood Swings
  • Better Metabolism
  • Skin And Nerve Function
  • Muscle Formation
  • Bone Remodelling And Growth
  • Liver Function
  • Reproductive System Function
  •  Cardiovascular System Function
  • Sleep
  • Memory And Learning
  • Digestion
  • Inflammation

Immune System Responses

All these functions mentioned above add to homeostasis. Homeostasis is the internal environment in our bodies. Modern-day experts now believe due to pain or fever. If you lose your body’s homeostasis, your ECS kicks in to help your body get back to its optimal activity.

  • Cannabis

Cannabis is a plant for sporting and therapeutic medication. Cannabis-based products come from the dried blooming tops, leaves, stems, and Cannabis sativa or hemp plant seeds. A portion of the cannabis plants is psychoactive or trippy. However, others are not. The power and equilibrium depend upon how the producer grows the plant.

Some of the methods of using cannabis are the following:

  • Smoking or vaping it
  • Preparing it as a tea
  • Cooking it as edibles, like brownies or confections
  • Applying it as a skin treatment
  • Eating it

There are at least 120 different components. Although doctors and experts are not sure of each of the components’ different advantages or medical benefits, one thing that proves cannabis is best for neuropathic causes. When patients do not or almost stop reacting to other medications, CBD and THC come into the frame and help as a messiah for some. This can help a person to heal faster. A psychoactive effect is an option, but in the end, both THC and CBD work the same.

  • Lipid metabolism

Lipid metabolism includes the combination of the underlying and practical lipids that are normal for particular issues and the corruption of lipids to fulfill the metabolic necessities of the body. Lipid metabolism is in a steady condition of dynamic harmony. This implies that a few lipids are continually oxidized to meet the body’s metabolic necessities, while others are integrated and kept away.

ECS are lipid metabolites that carry arachidonoyl moieties. These act as agonists at a set of cannabinoid-receptor proteins. The ECS and their related receptors are present all through the body and mind, where they direct a wide assortment of physiological capacities independently.

How Does THC Interact With ECS?

THC or Tetrahydrocannabinol is a type of compound that will put you through psychoactive experiences. In simple words, if you consume THC, you will get high. THC interfaces with your ECS by restricting to receptors just like endocannabinoids. It can tie to both CB1 and CB2 receptors. This permits it to have a scope of consequences for your body and psyche. For instance, THC may assist with healing pain. Yet, it can also cause suspicion and nervousness in some cases. Doctors and other experts are trying to create synthetic THC cannabinoids that connect with the ECS for more benefits.

How Does CBD Interact With ECS?

CBD or cannabidiol is another type of cannabinoid available in cannabis. Unlike THC, if you consume any product of CBD, you will not get high or deal with any psychoactive experiences. Endocannabinoid System and CBD almost share similar properties, making them help us fight against stress, pain, fatigue. The only difference is that CBD is present in the cannabis plant, and ECS is present in the human body.

Experts have not yet claimed any proven results of how ECS works with CBD. Although, one thing they are sure of is that, unlike THC, CBD cannot react to CB1 or CB2 receptors. While some experts believe CBD prevents ECS from breaking down, resulting in a better effect of CBD in the body, others believe there might be a hidden receptor that works to react to CBD. Even though the questions raise tons of confusion, one thing is for sure. CBD acts as a natural healer for those who suffer from appetite loss, mood swings, pain, fatigue, etc.

Experts worldwide are still to understand more about the ECS and its interaction with CBD. To understand more about it, we need to sit back with patience while the experts understand and clarify the movements or actions of CBD on the receptors.

ECS and Mental Health

When anxiety and fear get disproportional, they can hinder the physical and mental health of a person. Such outcomes might be because of tension-related neuropsychiatric issues like chronic anxiety, fear, and post-traumatic disorder. Plus, not all patients react to the as of now available pharmacotherapeutic treatments appropriately.

Until recently, proof for the association of the ECS in nervousness and fear has been formed. Which explains the job of the ECS in anxiety and tension may give new treatment options. One of the objectives to contemplate is presynaptically available in cannabinoid type 1 (CB1) receptor. The endogenous lipid ligands 2-arachidonoylglycerol (2-AG) and anandamide (AEA) blend postsynaptically and travel retrogradely to operate with CB1 receptors.

The outcome is considered as diminish synapse discharge. Different constituents of the ECS are the debasing proteins unsaturated fat amide hydrolase (FAAH) for AEA and monoacylglycerol lipase (MAGL) for 2-AG individually.
Considering the notable involvement of plenty of plethora of neurotransmitter systems in the regulation of anxiety and the capacity of the CB1 receptors in the concealment of synapse discharge in various neuronal subtypes. The ECS is recognized as one of the critical components of anxiety disorders.

The organization course of medications in pharmacological methodologies addresses the beginning stage in investigating the social outcomes, as anxiogenic and anxiolytic impacts of ECS upgrade. This is identified in the different brain areas. Regardless of the trouble to produce a physiological model that considers the tremendous measure of connections related to the ECS, two synapses have arisen as perspectives for the intricacy in anxiety conduct.

What About Endocannabinoids Deficiency?

The Endocannabinoid System, ECS, exists to screen a few of our body’s imperative natural systems. Its essential job is to help re-establish harmony in the human body and keep it in ideal condition. Some scientists accept that a flawed

The Endocannabinoid system could be the hidden reason for causes like migraine, fibromyalgia, and irritable bowel syndrome. While the idea isn’t consistently acknowledged among clinical bodies, there is a developing examination volume to prove the study.

Endocannabinoid inadequacy is the conviction that conditions can happen because of issues with the ECS. This can either be through an absence of endocannabinoids that the body creates or absent or inadequate receptors. If the body can’t keep up the equilibrium of its physiological systems, infections can happen. In our study cases, these infections are generally connected to our resistant system up until this point.

  • Migraine

Migraine is an exceptionally complex condition that includes motioning between various spaces of the mind and a few neurochemicals. The specific reason for migraines isn’t wholly perceived. However, present examples of AEA (anandamide) being involved in serotonin production and pain modulation.

  • Irritable Bowel Syndrome

IBS was the last condition viewed as influenced by an endocannabinoid inadequacy. Serotonin was thought to impact, as IBS victims have appeared to expand serotonin degrees in their blood. Nonetheless, this wasn’t the situation for all types of IBS. Cannabinoids would usually shape a vital piece of this treatment because of their impact on basic endocannabinoids like anandamide.

  • Fibromyalgia

Fibromyalgia is an ongoing, long-term disease that can leave victims in consistent pain. There is at present no medicine for the illness. However, up to this point, daily medication has had the option to ease the consequences. Serotonin is again considered to have critical inclusion in fibromyalgia, as did different cannabinoids. The consequences of the study present that cannabinoids have shown the capacity to impede spinal, fringe, and gastrointestinal instruments that advance agon.

The Bottom line

Endocannabinoid System is a detailed study that came into being while exploring THC in the year 1992. Ever since, experts, including the first explorer Dr. Lumir Hanus are trying to pull more confidential information about ECS. However, amidst tons of case studies and research, it is clear that ECS is a healthy cannabinoid existing in the body.

The advantages of ECS are astonishing yet complicated. While some experts believe it is naturally present in the body, others understand how the entire process works. The experts truly and mutually believe that ECS heals mental pain and physical pain, helping the patient relax and take proper rest.

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